Tomato steroidal alkaloids
In plants, and in vivo after tomatoes get eaten π
We are working to understand the profile and concentrations of tomato alkaloids across germplasm, their genetic control in fruits, and their absorption, distribution, metabolism, excretion, and health impact in those who enjoy tomatoes.
Here is some work we’ve published on the topic:
- Dzakovich MP, Goggans ML, Thomas-Ahner JM, Moran NE, Clinton SK, Francis DM, Cooperstone JL. Transcriptomics and metabolomics reveal tomato consumption alters hepatic xenobiotic metabolism and induces steroidal alkaloid metabolite accumulation in mice. April 18, 2023. bioRxiv
- Dzakovich MP, Francis DM, Cooperstone JL. Steroidal alkaloid biosynthesis is coordinately regulated and differs among tomatoes in the red-fruited clade. Plant Genome, 2022;15:e20192.
- Dzakovich MP, Hartman JL, Cooperstone JL.
A high-throughput extraction and analysis method for steroidal glycoalkaloids in tomato, Front Plant Sci, 2020;11:767.
– Also published a pre-print on bioRxiv - Cooperstone JL, Tober KA, Riedl KM, Teegarden MD, Cichon MJ, Francis DM, Schwartz SJ, Oberyszyn TA. Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations, Sci Reports, 2017;5:5106.
If you have trouble accessing any work, send Jess an email and she’d be happy to share the paper and its relevant data with you.
- Posted on:
- January 1, 0001
- Length:
- 1 minute read, 184 words
- Categories:
- tomato plants mammals after eating plants
- Tags:
- tomato alkaloids michael dzakovich mallory goggans jordan (jl) hartman maria sholola avery brewer daniel do
- See Also: