Tomato steroidal alkaloids

We are working to understand the profile and concentrations of tomato alkaloids across germplasm, their genetic control in fruits, and their absorption, distribution, metabolism, excretion, and health impact in those who enjoy tomatoes.

Here is some work we’ve published on the topic:

• Dzakovich MP, Francis DM, Cooperstone JL. Biosynthesis of steroidal alkaloids are coordinately regulated and differ among tomatoes in the red-fruited clade. bioRxiv, 2021,
• Dzakovich MP, Hartman JL, Cooperstone JL. A high-throughput extraction and analysis method for steroidal glycoalkaloids in tomato, Front Plant Sci, 2020;11:767.
  – Also published a pre-print on bioRxiv
• Cooperstone JL, Tober KA, Riedl KM, Teegarden MD, Cichon MJ, Francis DM, Schwartz SJ, Oberyszyn TA. Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations, Sci Reports, 2017;5:5106.

If you have trouble accessing any work, send Jess an email and she’d be happy to share the paper and its relevant data with you.