Tomato steroidal alkaloids

We are working to understand the profile and concentrations of tomato alkaloids across germplasm, their genetic control in fruits, and their absorption, distribution, metabolism, excretion, and health impact in those who enjoy tomatoes.

Here is some work we’ve published on the topic:

• Sholola MJ, Goggans ML, Dzakovich MP, Francis DM, Jacobi SK, Cooperstone JL. Discovery of steroidal alkaloid metabolites and their accumulation in pigs after short-term tomato consumption. bioRxiv, February 8, 2024.
• Dzakovich MP, Goggans ML, Thomas-Ahner JM, Moran NE, Clinton SK, Francis DM, Cooperstone JL. Transcriptomics and metabolomics reveal tomato consumption alters hepatic xenobiotic metabolism and induces steroidal alkaloid metabolite accumulation in mice. Mol Nutr Food Res, 2024;68:2300239. Also published as a pre-print on bioRxiv: https://www.biorxiv.org/content/10.1101/2023.04.18.536606v1
• Dzakovich MP, Francis DM, Cooperstone JL. Steroidal alkaloid biosynthesis is coordinately regulated and differs among tomatoes in the red-fruited clade. Plant Genome, 2022;15:e20192.
• Dzakovich MP, Hartman JL, Cooperstone JL. A high-throughput extraction and analysis method for steroidal glycoalkaloids in tomato, Front Plant Sci, 2020;11:767.
  – Also published a pre-print on bioRxiv
• Cooperstone JL, Tober KA, Riedl KM, Teegarden MD, Cichon MJ, Francis DM, Schwartz SJ, Oberyszyn TA. Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations, Sci Reports, 2017;5:5106.

If you have trouble accessing any work, check here or send Jess an email and she’d be happy to share with you.