Metabolomics
Using untargeted metabolomics on plants, foods, cells, and mammals
Metabolomics allows the comprehensive profiling of hundreds to thousands of small molecules present within a system. By using this approach, we can understand how metabolic changes (in plants, cells, animals, or people) are affected by our research question, and generate new ideas we may not be able to a priori hypothesize.
Here is some work we’ve published on the topic:
- Roman-Reyna V, Heiden N, Butchacas J, Toth H, Cooperstone JL, Jacobs J. The timing of bacterial mesophyll infection shapes the leaf chemical landscape. Microbiology Spectrum, 2024:12;4:e04138-23.
- Pastuña JV, Quiroz-Moreno CD, Medina EJ, Cooperstone JL, Radice M, Peñuela-Mora MC, Almeida JR, Salazar Mogollon NG. Metabolite fingerprinting of Urospatha sagittifolia (Araceae) tubers at different growth stages by multi-platform metabolomics and molecular networking. Microchemical J, 2024;199:110058.
- Dzakovich MP, Goggans ML, Thomas-Ahner JM, Moran NE, Clinton SK, Francis DM, Cooperstone JL. Transcriptomics and metabolomics reveal tomato consumption alters hepatic xenobiotic metabolism and induces steroidal alkaloid metabolite accumulation in mice. Mol Nutr Food Res, 2024;68:2300239. Also published as a pre-print on bioRxiv: https://www.biorxiv.org/content/10.1101/2023.04.18.536606v1
- Emanuel I, Cooperstone JL, Hand-Peduto F. UHPLC-MS/MS identification of metabolites in winterberry fruit putatively associated with natural disease resistance to Diaporthe ilicicola. Phytopathology, 2024;114:93-101.
- Emanuel I, Cooperstone JL, Hand-Peduto F. Susceptibility screening of winterberry (Ilex verticillata) cultivars against latent fruit rot, and identification of metabolites correlated with rot-resistant phenotypes. J Environ Hortic, 2023;41:121-132.
- Bilbrey EA, Williamson K, Hatzakis E, Doud Miller D, Fresnedo Ramírez J, Cooperstone JL.
Integrating genomics and multi-platform metabolomics enables metabolite QTL detection in breeding-relevant apple germplasm. New Phytologist, 2021.
– Also published a pre-print on bioRxiv - Knobloch TJ, Ryan NM, Bruschweiler-Li L, Wang C, Bernier MC, Somogyi A, Yan PS, Cooperstone JL, Mo X, Bruschweiler RP, Weghorst CM, Oghumu S. Metabolic regulation of glycolysis and AMP activated protein kinase pathways during black raspberry-mediated oral cancer chemoprevention. Metabolites 2019;9(7):140.
- Teegarden MD, Schwartz SJ, Cooperstone JL. Profiling the impact of thermal processing on black raspberry phytochemicals using untargeted metabolomics. Food Chem, 2019;274:782-788.
- Teegarden MD, Knobloch TJ, Weghorst CM, Cooperstone JL, Peterson DG. [Storage conditions modulate the metabolomic profile of a black raspberry nectar beverage with minimal impact on bioactivity](DOI https://doi.org/10.1039/C8FO00639C). Food and Function, 2018;9:4593-4601.
- Cooperstone JL, Tober KA, Riedl KM, Teegarden MDg, Cichon MJ, Francis DM, Schwartz SJ, Oberyszyn TA. Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations. Sci Reports, 2017;5:5106.
If you have trouble accessing any work, check here or send Jess an email and she’d be happy to share with you.
- Posted on:
- September 20, 2021
- Length:
- 2 minute read, 406 words
- Categories:
- tomato apple black raspberry winterberry michael dzakovich matt teegarden jenna miller emma bilbrey jordan (jl) hartman daniel quiroz moreno annalise celano aaron wiedemer
- See Also: