Metabolomics allows the comprehensive profiling of hundreds to thousands of small molecules present within a system. By using this approach, we can understand how metabolic changes (in plants, cells, animals, or people) are affected by our research question, and generate new ideas we may not be able to a priori hypothesize.
Here is some work we’ve published on the topic:
- Bilbrey EA, Williamson K, Hatzakis E, Doud Miller D, Fresnedo Ramírez J, Cooperstone JL.
Integrating genomics and multi-platform metabolomics enables metabolite QTL detection in breeding-relevant apple germplasm. New Phytologist, 2021.
– Also published a pre-print on bioRxiv
- Knobloch TJ, Ryan NM, Bruschweiler-Li L, Wang C, Bernier MC, Somogyi A, Yan PS, Cooperstone JL, Mo X, Bruschweiler RP, Weghorst CM, Oghumu S. Metabolic regulation of glycolysis and AMP activated protein kinase pathways during black raspberry-mediated oral cancer chemoprevention. Metabolites 2019;9(7):140.
- Teegarden MD, Schwartz SJ, Cooperstone JL. Profiling the impact of thermal processing on black raspberry phytochemicals using untargeted metabolomics. Food Chem, 2019;274:782-788.
- Teegarden MD, Knobloch TJ, Weghorst CM, Cooperstone JL, Peterson DG. [Storage conditions modulate the metabolomic profile of a black raspberry nectar beverage with minimal impact on bioactivity](DOI https://doi.org/10.1039/C8FO00639C). Food and Function, 2018;9:4593-4601.
- Cooperstone JL, Tober KA, Riedl KM, Teegarden MDg, Cichon MJ, Francis DM, Schwartz SJ, Oberyszyn TA. Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations. Sci Reports, 2017;5:5106.
If you have trouble accessing any work, send Jess an email and she’d be happy to share the paper and its relevant data with you.